Dr. Gallitano: Sleep deprivation upregulates serotonin 2AR

The serotonin 2A (5-HT2A) receptor is widely distributed in the brain and plays a critical role in perception, cognition and psychosis. It is also responsible for the psychedelic effects of drugs, such as psilocybin (hallucinogenic mushrooms) and LSD. Abnormal 5-HT2A receptor function is associated with psychiatric disorders, including schizophrenia. The leading class of antipsychotic drugs used to treat schizophrenia targets 5-HT2A receptors to reduce symptoms of hallucinations and impaired cognition.